Endocrine Abstracts

Introduction: AGEs have been shown to be accumulated in granulosa cell layer from human ovaries in normal and in women with polycystic ovarian syndrome (PCOS) and insulin resistance. AGEs interfere with insulin signaling pathways of several target tissues and are implicated in insulin resistance mechanisms. There is evidence that within the ovary these pathways are also important for glucose metabolism and normal folliculogenesis. The effect of human glycated albumin (HGA) eit...